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Drs. Majumdar and Che Featured in eLife: “Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site”

The paper highlights a newly discovered molecule with the potential to provide analgesic pain relief with fewer side effects and less addictive properties than opioids. Majumdar and Che’s research team has been studying the molecule to determine its orientation and how it binds to opioid receptors.

The project is a result of ongoing research work in the Che lab aimed at comprehensively characterizing and dissecting the molecular mechanisms of opioid receptor signaling.

Access the manuscript here: